Non-Platform Fiction

I'm a completely non angsty person, so feel free to punch as hard as you want on this one.

I know that most non-fiction depends on a great platform; either you are famous already or you are writing about something insanely compelling(you accidentally spent a magical summer with chairman mao.). With that said, and while I acknowledge that this is a completely logical and fair way to do business, is there any space for someone with an interesting non-fiction concept, written with humor and wit?

I'm talking about something without historic signifigance or tear-jerking poignancy, but still a concept which an average person might find interesting and amusing. I'm purposely leaving out my concept for two reasons: you don't want to waste your time reading it, and I want more of a general industry answer than a specific acceptance or rejection of my ideas.

David Sedaris makes a pretty good living talking about wacky neighbors and childhood memories, which would make a terrible platform if you pitched it like that, but he's actually really funny and, I think, deserving of his bestseller status. At least for When You Are Engulfed in Flames.

In short: My answer is yes.